Is the angel room seen only when playing the WotL expansion or can you get them in the original game too? What does 'refuse a deal with the devil' mean? Do you have to enter the Devil room at all? Does it matter if you don't have enough heart containers to make the trade? When I'm feeling desperate for an Angel Room, I even shoot the devil statue before leaving. I got the 'Crack the Sky' item on the first item room, and used it on every boss so far up to the fourth floor, and every time I used it I got the angel. Needs confirmation and someone besides a 10 year old to write it down. Either these are known ways, or possible ways. They aren't 'known' if it's only a possibility. 'These are the known ways of possibly increasing the chances:' O noes! Good news was Satan went down easy and it was a super fun play-through, although I wasn't expecting the Angel Room to be a trick. I was waltzing through the womb like it was nothing and decided I would try to fight Isaac again (he kicked my butthole the first time, since I had a high firerate but not enough DPS), and carelessly strolled into the Angel Room and down the trapdoor to be confronted with Sheol instead. I had the awesomeness of getting Polyphemus with The Sad Onion and several Tears Up pills (thanks to getting a Lucky Foot in the first Item Room) and Meat Boy (invaluable for knights, etc). I found a Scapular in the angel room, can anyone confirm this has happend to them before it is added to the list? Ironic indeed!